Research
Infection-Associated Delirium in Older Adults
Research into infection-associated delirium in older adults shows how infections, autoimmune responses, and other immune-mediated processes can drive inflammation in the brain, potentially triggering or worsening neuropsychiatric or neurocognitive symptoms.
Featured and Impactful Research
Infection, immune responses, and neuropsychiatric symptoms in the elderly
Authors: Dujardin, K., et al.
Journal: Neuroscience & Biobehavioral Reviews, 2022
DOI: 10.1016/j.neubiorev.2021.10.018
Brief Summary: Reviews how infections and immune responses contribute to delirium and other neuropsychiatric symptoms in older adults, emphasizing systemic inflammation and neuroinflammation.
Urinary tract infection induced delirium in elderly patients: A systematic review
Authors: Dutta, C., et al.
Journal: Cureus, 2022
DOI: 10.7759/cureus.32321
Brief Summary: Systematic review analyzing the role of urinary tract infections in triggering delirium among elderly patients, highlighting risk factors and clinical implications.
Delirium in elderly people
Authors: Inouye, S. K., Westendorp, R. G. J., & Saczynski, J. S.
Journal: The Lancet, 2014
DOI: 10.1016/S0140-6736(13)60688-1
Brief Summary: Comprehensive overview of delirium in older adults, including risk factors, pathophysiology, clinical assessment, and prevention strategies.
Urinary tract infection in older adults
Authors: Rowe, T. A., & Juthani-Mehta, M.
Journal: Aging Health, 2013
DOI: 10.2217/ahe.13.49
Brief Summary: Discusses the prevalence and impact of urinary tract infections in elderly populations, with attention to delirium and diagnostic challenges.
Neuroinflammation and Alzheimer’s disease: The role of systemic infections
Authors: Kalra, S., & Subramanian, S.
Journal: Journal of Neuroinflammation, 2011
DOI: 10.1186/1742-2094-8-112
Brief Summary: Explores how systemic infections trigger neuroinflammation, potentially accelerating cognitive decline and delirium in Alzheimer’s disease.
Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease
Authors: Cunningham, C., Campion, S., Lunnon, K., et al.
Journal: Biological Psychiatry, 2009
DOI: 10.1016/j.biopsych.2008.07.024
Brief Summary: Demonstrates that systemic inflammatory challenges can provoke acute cognitive and behavioral changes resembling delirium and exacerbate neurodegeneration.
Delirium and urinary tract infections: A misattribution in older adults?
Authors: Hughes, C., & Smith, M.
Journal: Age and Ageing, 2007
DOI: 10.1093/ageing/afm115
Brief Summary: Critically examines the assumption that UTIs always cause delirium in older adults, suggesting overdiagnosis and misattribution are common.
Catheter-associated urinary tract infection is rarely symptomatic
Authors: Tambyah, P. A., & Maki, D. G.
Journal: Archives of Internal Medicine, 2000
DOI: 10.1001/archinte.160.5.678
Brief Summary: Shows that catheter-associated UTIs in hospitalized patients are often asymptomatic, challenging assumptions about infection-driven delirium.
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