Research

NMaDAR Encephalitis

Research into NMaDAR Encephalitis shows how infections, autoimmune responses, and other immune-mediated processes can drive inflammation in the brain, potentially triggering or worsening neuropsychiatric or neurocognitive symptoms

Featured and Impactful Research

Autoantibodies in neurological disease

Authors: Prüss, H.

Journal: Nature Reviews Immunology, 2021

DOI: 10.1038/s41577-021-00633-8

Brief Summary: Reviews the role of autoantibodies in neurological disorders, highlighting mechanisms, diagnostic approaches, and therapeutic implications.

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Herpes simplex virus–induced anti-NMDA receptor encephalitis: A case of molecular mimicry?

Authors: Leypoldt, F., Armangue, T., Dalmau, J., & Graus, F.

Journal: Neurology: Neuroimmunology & Neuroinflammation, 2015

DOI: 10.1212/NXI.0000000000000113

Brief Summary: Describes a case linking HSV infection to anti-NMDA receptor encephalitis, suggesting molecular mimicry as a pathogenic mechanism.

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Autoimmune encephalitis in children

Authors: Armangue, T., Leypoldt, F., & Dalmau, J.

Journal: Journal of Child Neurology, 2013

DOI: 10.1177/0883073812473510

Brief Summary: Provides an overview of pediatric autoimmune encephalitis, including clinical presentation, diagnostic criteria, and immunotherapy strategies.

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Neuronal autoantigens—pathogenesis, associated disorders and antibody testing

Authors: Lancaster, E., & Dalmau, J.

Journal: Nature Reviews Neurology, 2012

DOI: 10.1038/nrneurol.2012.110

Brief Summary: Summarizes key neuronal autoantigens, their associated disorders, and approaches for antibody detection, emphasizing clinical relevance.

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Anti-NMDA-receptor encephalitis: Case series and analysis of the effects of antibodies

Authors: Dalmau, J., Tüzün, E., Wu, H. Y., Masjuan, J., Rossi, J. E., Voloschin, A., Baehring, J., Shimazaki, H., Koide, R., King, D., … Lynch, D. R.

Journal: The Lancet Neurology, 2007

DOI: 10.1016/S1474-4422(07)70324-3

Brief Summary: Reports a case series of anti-NMDA receptor encephalitis, detailing clinical features, antibody effects, and responses to immunotherapy.

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