Research
OCD (Obsessive-compulsive disorder)
Research into OCD (Obsessive-compulsive disorder) shows how infections, autoimmune responses, and other immune-mediated processes can drive inflammation in the brain, potentially triggering or worsening neuropsychiatric or neurocognitive symptoms
Featured and Impactful Research
SARS-CoV-2/COVID-19 associated pediatric acute-onset neuropsychiatric syndrome: A case report of female twin adolescents
Authors: Ayşegül, E.
Journal: Psychiatry Research Case Reports, 2022
DOI: 10.1016/j.psycr.2022.100074
Brief Summary: Reports on twin adolescents who developed acute-onset OCD-like symptoms following COVID-19 infection, highlighting potential viral triggers for neuropsychiatric syndromes.
Clinical management of pediatric acute-onset neuropsychiatric syndrome: Part I—psychiatric and behavioral interventions
Authors: Frankovich, J., Swedo, S., Murphy, T., Dale, R., Agalliu, D., Williams, K., et al.
Journal: Journal of Child and Adolescent Psychopharmacology, 2017
DOI: 10.1089/cap.2016.0145
Brief Summary: Provides evidence-based guidance on psychiatric and behavioral management of children with PANS, including OCD symptoms, emphasizing early intervention and multidisciplinary care.
The immunology of obsessive-compulsive disorder
Authors: Murphy, T. K., Storch, E. A., Goodman, W. K., & Geffken, G. R.
Journal: Psychiatric Clinics of North America, 2012
DOI: 10.1016/j.psc.2011.11.004
Brief Summary: Reviews immune system involvement in OCD, discussing autoimmunity, inflammatory pathways, and implications for treatment of pediatric and adult patients.
Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: Clinical description of the first 50 cases
Authors: Swedo, S. E., Leonard, H. L., Garvey, M., Mittleman, B., Allen, A. J., Perlmutter, S., et al.
Journal: American Journal of Psychiatry, 1998
DOI: 10.1176/ajp.155.2.264
Brief Summary: Describes the initial 50 PANDAS cases, linking sudden-onset OCD and tics to streptococcal infections, foundational for understanding immune-related OCD.
Stay Informed
Sign up to receive research updates, news, and key developments in the field of brain immunology.