Research
PANS (Pediatric Acute-Onset Neuropsychiatric Syndrome)
Research into PANS (Pediatric Acute-Onset Neuropsychiatric Syndrome) shows how infections, autoimmune responses, and other immune-mediated processes can drive inflammation in the brain, potentially triggering or worsening neuropsychiatric or neurocognitive symptoms
Featured and Impactful Research
Defining Clinical Course of Patients Evaluated for Pediatric Acute-Onset Neuropsychiatric Syndrome: Phenotypic Classification Based on 10 Years of Clinical Data
Authors: Stanford Immune Behavioral Health Clinic
Journal: Developmental Neuroscience, 2024
DOI: 10.1159/000545598
Brief Summary: Analyzes 10 years of longitudinal data to define clinical trajectories in PANS, identifying relapsing-remitting patterns and proposing standardized terminology for disease course.
Pediatric acute onset neuropsychiatric syndrome (PANS) and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS): Immunological features underpinning controversial entities
Authors: Leonardi, L., Perna, C., Bernabei, I., Fiore, M., Ma, M., Frankovich, J., Tarani, L., & Spalice, A.
Journal: Children, 2024
DOI: 10.3390/children11091043
Brief Summary: This study explores the immunological profiles of PANS and PANDAS, highlighting overlapping immune features.
Clinical management of pediatric acute onset neuropsychiatric syndrome: Part III — Treatment and prevention of infections
Authors: Cooperstock, M. S., Swedo, S. E., Pasternack, M. S., & Murphy, T. K.
Journal: Journal of Child and Adolescent Psychopharmacology, 2017
DOI: 10.1089/cap.2016.0151
Brief Summary: Provides guidance on infection management in PANS, emphasizing prevention and early treatment to reduce neuropsychiatric exacerbations.
Clinical management of pediatric acute onset neuropsychiatric syndrome: Part II — Use of immunomodulatory therapies
Authors: Frankovich, J., Swedo, S., Murphy, T., Dale, R. C., Agalliu, D., Williams, K., et al.
Journal: Journal of Child and Adolescent Psychopharmacology, 2017
DOI: 10.1089/cap.2016.0148
Brief Summary: Reviews immunomodulatory treatments in PANS, including corticosteroids, IVIG, and plasma exchange, with clinical recommendations.
Clinical management of pediatric acute onset neuropsychiatric syndrome: Part I — Psychiatric and behavioral interventions
Authors: Thienemann, M., Murphy, T., Leckman, J. F., Shaw, R., Williams, K., Kapphahn, C., et al.
Journal: Journal of Child and Adolescent Psychopharmacology, 2017
DOI: 10.1089/cap.2016.0145
Brief Summary: Focuses on psychiatric and behavioral treatment strategies for managing acute and chronic symptoms in PANS.
Clinical evaluation of youth with pediatric acute onset neuropsychiatric syndrome (PANS): Recommendations from the 2013 PANS Consensus Conference
Authors: Chang, K., Frankovich, J., Cooperstock, M., Cunningham, M. W., Latimer, M. E., Murphy, T. K., et al.
Journal: Journal of Child and Adolescent Psychopharmacology, 2015
DOI: 10.1089/cap.2014.0084
Brief Summary: Provides consensus-based recommendations for evaluation and diagnosis of PANS, emphasizing multidisciplinary assessment.
From research subgroup to clinical syndrome: Modifying the PANDAS criteria to describe PANS (pediatric acute onset neuropsychiatric syndrome)
Authors: Swedo, S. E., Leckman, J. F., & Rose, N. R.
Journal: Pediatrics & Therapeutics, 2012
DOI: 10.4172/2161-0665.1000113
Brief Summary: Proposes expanded diagnostic criteria transitioning from PANDAS to PANS to encompass a broader range of acute-onset neuropsychiatric conditions.
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