Research

Sydenham’s chorea

Authors: Cardoso, F.

Journal: Handbook of Clinical Neurology, 2011

DOI: 10.1016/B978-0-444-52014-2.00016-1

Brief Summary: Reviews clinical features, pathophysiology, and management of Sydenham’s chorea, highlighting neurological and neuropsychiatric sequelae.

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Corticosteroids for the treatment of Sydenham’s chorea

Authors: Barash, J., et al.

Journal: Pediatric Neurology, 2005

DOI: 10.1016/j.pediatrneurol.2004.09.002

Brief Summary: Evaluates the effectiveness of corticosteroid therapy in managing Sydenham’s chorea, reporting symptomatic improvement in treated patients.

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Treatment of Sydenham’s chorea with intravenous immunoglobulin, plasma exchange, or prednisone

Authors: Garvey, M. A., et al.

Journal: Journal of Child Neurology, 2005

DOI: 10.1177/088307380502000507

Brief Summary: Compares immunomodulatory treatments for SC, showing potential benefits of IVIG, plasma exchange, and prednisone for severe cases.

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Randomized double-blind study with prednisone in Sydenham’s chorea

Authors: Paz, J. A., et al.

Journal: Pediatric Neurology, 2006

DOI: 10.1016/j.pediatrneurol.2005.12.010

Brief Summary: Demonstrates that prednisone significantly reduces symptom duration in children with Sydenham’s chorea compared to placebo.

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Molecular mimicry, autoimmunity, and infection: The cross-reactive antigens of group A streptococci and their sequelae

Authors: Cunningham, M. W.

Journal: Microbiology Spectrum, 2006

DOI: 10.1128/microbiolspec.MDNA3-0016-2014

Brief Summary: Discusses how immune responses to group A streptococci can lead to autoimmunity affecting the basal ganglia, underlying SC and related disorders.

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Autoimmunity and the basal ganglia: New insights into old diseases

Authors: Dale, R. C.

Journal: QJM: An International Journal of Medicine, 2003

DOI: 10.1093/qjmed/hcg026

Brief Summary: Explores autoimmune mechanisms in basal ganglia disorders including SC, emphasizing antibody-mediated neuronal dysfunction.

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High prevalence of obsessive-compulsive symptoms in patients with Sydenham’s chorea

Authors: Swedo, S. E., et al.

Journal: American Journal of Psychiatry, 1989

DOI: 10.1176/ajp.146.2.246

Brief Summary: Reports frequent OCD symptoms in children with SC, highlighting neuropsychiatric comorbidities linked to basal ganglia dysfunction.

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Obsessive-compulsive symptoms in Sydenham’s chorea

Authors: Asbahr, F. R., et al.

Journal: American Journal of Psychiatry, 1994

DOI: 10.1176/ajp.151.5.627

Brief Summary: Examines the occurrence and severity of OCD symptoms in SC, reinforcing the connection between infection, autoimmunity, and neuropsychiatric manifestations.

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Prevention of rheumatic fever: Treatment of the preceding streptococcic infection

Authors: Denny, F. W., Wannamaker, L. W., Brink, W. R., Rammelkamp, C. H., Jr., & Custer, E. A.

Journal: JAMA, 1950

DOI: 10.1001/jama.1950.02910040074024

Brief Summary: Demonstrates that early treatment of streptococcal infections prevents rheumatic fever, indirectly reducing the risk of SC.

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On chorea and choreiform affections

Authors: Osler, W.

Journal: London: H.K. Lewis, 1894

DOI: N/A

Brief Summary: Classic text describing clinical observations of chorea, its variants, and associated neurological manifestations.

Rheumatic fever and rheumatic heart disease: Report of a WHO expert consultation

Authors: World Health Organization

Journal: Geneva: WHO, 2010

DOI: N/A

Brief Summary: WHO report summarizing global epidemiology, prevention, and treatment of rheumatic fever, including its neurological manifestation, Sydenham’s chorea.

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